Dr. Srigiridhar Kotamraju is working as a Principal Scientist in the Department of Applied Biology. He received his Master's degree (life sciences) in 1993 from the University of Hyderabad. He obtained his Ph.D. in Biochemistry 1999 from the National Institute of Nutrition Hyderabad.
From 1999-2007 he worked as a Research Scientist at the Medical College of Wisconsin (MCW), Milwaukee, USA, wherein; he was involved in investigating the role of free radicals in disease pathologies. He then moved back to India in 2007 and worked as a senior scientist at the Institute of Life Sciences for a short time. In 2008, he received Ramanujan Fellowship from the Dept. of Science and Technology, India.
Dr. Srigiridhar’s lab research interests are majorly focused on 1) Understanding the molecular mechanisms involved in tumor progression, cancer cell metastasis, and drug resistance along with detailed mechanisms of certain small molecules in mediating the anti-proliferative effects. 2) Mechanisms involved in regulating monocyte-to-macrophage differentiation. 3) Oxidant-induced endothelial dysfunction and also the epigenetic alterations induced during age-associated atherosclerosis, a major cardiovascular disorder. The group also employs certain novel mitochondria-targeted molecules for their age delaying and anti-anti-atherosclerotic effects and the mechanisms involved during these processes. All these studies are being carried out in, appropriate cell and animal models.